International Journal of Obstetric Anesthesia
Volume 15, Issue 1 , Pages 7-12, January 2006

Evaluation of the platelet function analyzer (PFA-100®) vs. the thromboelastogram (TEG) in the parturient☆

  • Y. Beilin

      Affiliations

    • Corresponding Author InformationCorrespondence to: Yaakov Beilin, MD, Department of Anesthesiology, Box 1010, The Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029-6574, USA. Tel.: +212 241 7467; fax: +212 426 2009.
    • ,
  • I. Arnold
    • ,
  • S. Hossain

Departments of Anesthesiology, Obstetrics, Gynecology & Reproductive Sciences, and Biomathematical Sciences, Mount Sinai School of Medicine of New York University, New York, NY, USA

Accepted 1 April 2005.

Yaakov Beilin MD, Departments of Anesthesiology and Obstetrics, Gynecology & Reproductive Sciences; Ittamar Arnold BS, Department of Anesthesiology; Sabera Hossain MS, Department of Biomathematical Sciences, Mount Sinai School of Medicine of New York University, New York, USA.

Background

The platelet function analyzer (PFA-100®) is a bedside test of coagulation designed to evaluate platelet function. It measures the time required for whole blood to occlude a membrane impregnated with either epinephrine (EPI) or adenosine 5′diphosphate (ADP). The results are reported as closure time (CT-EPI or CT-ADP) in seconds. The thromboelastogram (TEG) measures whole blood clotting and the maximum amplitude (MA) correlates with platelet count and function. We wished to establish whether there is a correlation between the CT and platelet count, between the CT and MA, and between the MA and platelet count.

Methods

Platelet count, CT, and MA were measured in blood drawn from 172 healthy term parturients using the PFA-100®.

Results

We were unable to detect a significant correlation between the CT-EPI and platelet count (r=−0.1, P=0.21), or the CT-ADP and platelet count (r=−0.02, P=0.83). We also did not find a correlation between the CT-EPI and MA (r=−0.13, P=0.12) or between the CT-ADP and MA (r=−0.11, P=0.19). However, we found a significant correlation between platelet count and MA (r=0.33, P<0.001).

Conclusions

We conclude that the CT does not correlate with the platelet count or MA in the parturient, but the TEG does. Therefore the TEG may be a better tool to evaluate coagulation in the parturient with thrombocytopenia.

Keywords: Platelets, Epidural hematoma, Platelet Function Analyzer (PFA-100®), Thromboelastogram

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☆ Financial support was provided in part by Dade Behring, Inc, Newark, DE, and in part from the Department of Anesthesiology, Mount Sinai School of Medicine of New York University. The manuscript was presented in part at the 33rd Annual meeting of The Society for Obstetrical Anesthesia and Perinatology, San Diego, California, April 28, 2001.

PII: S0959-289X(05)00086-5

doi:10.1016/j.ijoa.2005.04.013

International Journal of Obstetric Anesthesia
Volume 15, Issue 1 , Pages 7-12, January 2006

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