International Journal of Obstetric Anesthesia
Volume 16, Issue 1 , Pages 29-34, January 2007

Recombinant factor VIIa in massive postpartum haemorrhage

  • D. Karalapillai
    • ,
  • P. Popham

      Affiliations

    • Corresponding Author InformationCorrespondence to: Dr. Philip Popham, BSc, MBBS, FRCA, MD, Senior Principal Anaesthetist, affiliated to the Department of Obstetrics and Gynaecology, University of Melbourne, Australia.

Department of Anaesthesia, Royal Women’s Hospital, Carlton, Victoria, Australia

Accepted 1 September 2006. published online 26 November 2006.

Dharshi Karalapillai, MBBS, FANZCA, Visiting Medical Officer, Philip Popham, BSc, MBBS, FRCA, MD, Senior Principal Anaesthetist, affiliated to the Department of Obstetrics and Gynaecology, University of Melbourne, Australia.

Summary 

Massive postpartum haemorrhage is a major cause of maternal and fetal morbidity and mortality. Management mainstays include transfusion therapy, uterotonic agents and surgery. The “off label” use of recombinant activated factor VII appears to have an evolving role in the management of massive postpartum haemorrhage refractory to conventional treatments. The current literature is reviewed.

Keywords: Postpartum haemorrhage, Factor VIIa, Anaesthesia, Obstetrics

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PII: S0959-289X(06)00159-2

doi:10.1016/j.ijoa.2006.09.001

International Journal of Obstetric Anesthesia
Volume 16, Issue 1 , Pages 29-34, January 2007

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