International Journal of Obstetric Anesthesia
Volume 16, Issue 2 , Pages 122-127 , April 2007

Prevention of postoperative nausea and vomiting after intrathecal morphine for cesarean section: a randomized comparison of dexamethasone, droperidol, and a combination

,Accepted 1 November 2006.

References 

  1. Caranza R, Jeyapalan I, Buggy DJ. Central neuraxial opioid analgesia after caesarean section: comparison of epidural diamorphine and intrathecal morphine. Int J Obstet Anesth. 1999;8:90–93
  2. Paech M J, Pavy T J, Orlikowski C E, et al. Postoperative intraspinal opioid analgesia after Caesarean section: a randomised comparison of subarachnoid morphine and epidural pethidine. Int J Obstet Anesth 2000; 9: 238–5.
  3. Italian Group for Antiemetic Research . Dexamethasone, granisetron, or both for the prevention of nausea and vomiting during chemotherapy for cancer. N Engl J Med. 1995;332:r1–r5
  4. Wang JJ, Ho ST, Lee SC, Liu YC, Liu YH, Liao YC. The prophylactic effect of dexamethasone on postoperative nausea and vomiting in women undergoing thyroidectomy:a comparison of droperidol with saline. Anesth Analg. 1999;89:200–203
  5. Balki M, Carvalho JC. Intraoperative nausea and vomiting during cesarean section under regional anesthesia. Int J Obstet Anesth. 2005;14:230–241
  6. Tzeng JI, Wang JJ, Ho ST, Tang CS, Liu YC, Lee SC. Dexamethasone for prophylaxis of nausea and vomiting after epidural morphine for post-caesarean section analgesia: comparison of droperidol with saline. Br J Anaesth. 2000;85:865–868
  7. Italian Group for Antiemetic Research . Ondansetron versus metoclopramide, both combined with dexamethasone, in the prevention of cisplatin-induced delayed emesis. J Clin Oncol. 1997;15:124–130
  8. Fujii Y, Tanaka H, Toyooka H. Granisetron-dexamethasone combination reduces postoperative nausea and vomiting. Can J Anaesth. 1995;42:387–390
  9. Sniadach MS, Alberts MS. A comparison of the prophylactic antiemetic effect of ondansetron and droperidol on patients undergoing gynecologic laparoscopy. Anesth Analg. 1997;85:797–800
  10. Pandit SK, Kothary SP, Pandit UA, Randel G, Levy L. Dose-response study of droperidol and metoclopramide as antiemetics for outpatient anesthesia. Anesth Analg. 1989;68:798–802
  11. Heffernan AM, Rowbotham DJ. Postoperative nausea and vomiting: time for balanced antiemesis?. Br J Anaesth. 2000;85:675–677
  12. Ho ST, Wang JJ, Tzeng JI, Liu HS, Ger LP, Liaw WJ. Dexamethasone for preventing nausea and vomiting associated with epidural morphine: a dose ranging study. Anesth Analg. 2001;92:745–748
  13. Tzeng JI, Hsing CH, Chu CC, Chen YH, Wang JJ. Low-dose dexamethasone reduces nausea and vomiting after epidural morphine: a comparison of metoclopramide with saline. J Clin Anesth. 2002;14:19–23
  14. Nortcliffe SA, Shah J, Buggy DJ. Prevention of postoperative nausea and vomiting after spinal morphine for Caesarean section: comparison of cyclizine, dexamethasone and placebo. Br J Anaesth. 2003;90:665–670
  15. Tan PH, Liu K, Peng CH, Yang LC, Lin CR, Lu CY. The effect of dexamethasone on postoperative pain and emesis after intrathecal neostigmine. Anesth Analg. 2001;92:228–232
  16. Tavorath R, Hesketh PJ. Drug treatment of chemotherapy-induced delayed emesis. Drugs. 1996;52:639–648
  17. Holte K, Kehlet H. Perioperative single dose glucocorticoid administration: pathophysiological effects and clinical implications. J Am Coll Surg. 2002;195:694–712
  18. Callery MP. Preoperative steroids for laparoscopic surgery. Ann Surg. 2003;238:661–662
  19. Dahl JB, Jeppesen IS, Jørgensen H, Wetterslev J, Møiniche S. Intraoperative and postoperative analgesic efficacy and adverse effects of intrathecal opioids in patients undergoing cesarean section with spinal anesthesia. Anesthesiology. 1999;91:1919–1927
  20. Fortney JT, Gan TJ, Graczyk S, et al. A comparison of the efficacy, safety, and patient satisfaction of ondansetron versus droperidol as antiemetics for elective outpatient surgical procedures: S3A-409 and S3A-410 Study Groups. Anesth Analg. 1998;86:731–738
  21. Nesek-Adam V, Grizelj-Stojcic E, Mrsic V, Smiljanic A, Rasic Z, Cala Z. Prophylactic antiemetics for laparoscopic cholecystectomy: droperidol, metoclopramide, and droperidol plus metoclopramide. J Laparoendosc Adv Surg Tech A. 2004;14:212–218
  22. Wu O, Belo SE, Koutsoukos G. Additive anti-emetic efficacy of prophylactic ondansetron with droperidol in out-patient gynecological laparoscopy. Can J Anaesth. 2000;47:529–536
  23. Scuderi PE. Droperidol:Many questions, few answers. Anesthesiology. 2003;98:289–290
  24. Dershwitz M. Droperidol: should the black box be light gray?. J Clin Anesth. 2002;14:598–603
  25. Bailey P, Norton R, Karan S. The FDA droperidol warning: is it justified?. Anesthesiology. 2002;97:288–289
  26. Reves JG, Glass PSA, Lubarsky DA, McEvoy MD. Intravenous Nonopioid Anesthetics. In:  Miller RD editors. Anesthesia. sixth ed.. Philadelphia: Elsevier Churchill Livingstone; 2005;p. 362
  27. Henzi I, Walder B, Tramer MR. Dexamethasone for the preventionc of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg. 2000;90:186–193
  28. Sagar S. The current role of anti-emetic drugs in oncology: a recent revolution in patient symptom control. Cancer Treat Rev. 1991;18:95–135
  29. Sauerland S, Nagelschmidt M, Mallmann P, Neugebauer EA. Risks and benefits of preoperative high dose methylprednisolone in surgical patients:a systematic review. Drug Saf. 2000;23:449–461
  30. Henzi I, Walder B, Tramer MR. Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg. 2000;90:186–194
  31. Alhashemi JA, Crosby ET, Grodecki W, Duffy PJ, Hull KA, Gallant C. Treatment of intrathecal morphine-induced pruritus following caesarean section. Can J Anaesth. 1997;44:1060–1065

☆ This work was supported in part by the National Science Council, Grant NSC 93-2314-B-214-011.

PII: S0959-289X(06)00199-3

doi: 10.1016/j.ijoa.2006.11.004

International Journal of Obstetric Anesthesia
Volume 16, Issue 2 , Pages 122-127 , April 2007

Article Tools