International Journal of Obstetric Anesthesia
Volume 17, Issue 1 , Pages 3-8 , January 2008

Prescribing intramuscular opioids for labour analgesia in consultant-led maternity units: a survey of UK practice

,Accepted 1 February 2007.

References 

  1. Chamberlain G, Steer PJ. Pain and Its Relief in Childbirth: A Survey by the National Birthday Trust in the United Kingdom. Edinburgh: Churchill Livingstone; 1993;
  2. Findley R, Chamberlain G. ABC of labour care – Relief of pain. BMJ. 1999;318:927–930
  3. Ramin SM, Gambling DR, Lucas MJ, Sharma SK, Sidawi JE, Leveno KJ. Randomized trial of epidural versus intravenous analgesia during labor. Obstet Gynecol. 1995;86:783–789
  4. Olofsson C, Ekblom A, Ekman-Ordeberg G, Hjelm A, Irestedt L. Lack of analgesic effect of systemically administered morphine or pethidine on labour pain. Br J Obstet Gynaecol. 1996;103:968–972
  5. Bricker L, Lavender T. Parenteral opioids for labor pain relief: a systematic review. Am J Obstet Gynecol. 2002;186:S94–S109
  6. Elbourne D, Wiseman RA. Types of intramuscular opioids for maternal pain relief in labour. The Cochrane Database of Systematic Reviews. 2000;2:1469–1493
  7. Nissen E, Lilja G, Matthiesen AS, Ransjo-Ardvidsson AB, Uvnas-Moberg K, Widstrom AM. Effects of maternal pethidine on infants’ developing breast feeding behaviour. Acta Paediatr. 1995;84:140–145
  8. CRAG Working Group on Maternity Services. Report on Pain Relief in Labour (MSP 02/96). Edinburgh: HMSO, 1996.
  9. Fairlie FM, Walker JJ. Intramuscular opioids for maternal pain relief in labour: a randomised controlled trial comparing pethidine with diamorphine. Br J Obstet Gynaecol. 1999;106:1181–1187
  10. Lund CJ, Harris JW. The use of heroin (diacetyl-morphine) in labour: a report of 454 deliveries. Am J Obstet Gynecol. 1943;45:980–991
  11. McInnes RJ, Hillan E, Clark D, Gilmour H. Diamorphine for pain relief in labour: a randomised controlled trial comparing intramuscular injection and patient-controlled analgesia. Br J Obstet Gynaecol. 2004;111:1081–1089
  12. Benthin W. Schmerzlinderung in der Geburt durch Dolantin. Dtsch Med Wschr. 1940;66:760–762
  13. Ransjo-Arvidson AB, Matthieson AS, Lilja G, Nissen E, Widstrom AM, Uvnas-Moberg K. Maternal analgesia during labor disturbs newborn behavior: effects on breastfeeding, temperature and crying. Birth. 2001;28:5–12
  14. Moya F, Thorndike D. The effects of drugs used in labor on the fetus and newborn. Clin Pharmacol Ther. 1962;4:628–639
  15. Tomson G, Garle RI, Thalme B, Nisell H, Nylund L, Rane A. Maternal kinetics and transplacental passage of pethidine during labour. Br J Clin Pharmacol. 1982;13:653–659
  16. Molloy A. Does pethidine still have a place in therapy?. Aust Prescr. 2002;25:12–13
  17. Aly E, Shilling RS. Are we willing to change?. Anaesthesia. 2000;55:419–420
  18. Husemeyer RP, Cummings AJ, Rosenkiewicz JR, Davenport HT. A study of pethidine kinetics and analgesia in women in labour following intravenous, intramuscular and epidural administration. Br J Clin Pharmacol. 1982;13:171–176
  19. Jackson MB, Robson PJ. Preliminary clinical and pharmacokinetic experiences in the newborn when meptazinol is compared with pethidine as an obstetric analgesic. Postgrad Med J 1983; 59 Suppl 1: 47–51.
  20. Freeman RM, Moreland TA, Blair AW. Diamorphine, the obstetric analgesic: a neurobehavioural and phamacokinetic study in the neonate. J Obstet Gynaecol. 1982;3:102–106
  21. Moreland TA, Brice JE, Mohamdee O, Walker CH. The influence of dose-delivery time interval on neonatal pethidine levels. Acta Obstet Gynecol Scand. 1983;62:549–553
  22. Belfrage P, Boreus LO, Hartvig P, Irestedt L, Raabe N. Neonatal depression after obstetrical analgesia with pethidine. The role of the injection-delivery time interval and of the plasma concentrations of pethidine and norpethidine. Acta Obstet Gynecol Scand. 1981;60:43–49
  23. Nel CP, Bloch B, Rush JM. A comparison of meptazinol and pethidine for pain relief during the first stage of labour. S Afr Med J. 1981;59:908–910
  24. Morrison CE, Dutton D, Howie H, Gilmour H. Pethidine compared with meptazinol during labour. A prospective randomised double-blind study in 1100 patients. Anaesthesia. 1987;42:7–14
  25. Nicholas AD, Robson PJ. Double-blind comparison of meptazinol and pethidine in labour. Br J Obstet Gynaecol. 1982;89:318–322
  26. Nimmo WS, Wilson J, Prescott LF. Narcotic analgesia and delayed gastric emptying during labour. Lancet. 1975;1:890–893
  27. Moore J, Carson RM, Hunter RJ. A comparison of the effects of pentazocine and pethidine administered during labour. J Obstet Gynaecol Br Commonw. 1970;77:830–836
  28. Tsui MHY, Ngan Kee W, NG FF, Lau TK. A double blinded randomised placebo-controlled study of intramuscular pethidine for pain relief in the first stage of labour. Br J Obstet Gynaecol 2004; 111: 648-55.
  29. Wilson CM, McClean E, Moore J, Dundee JW. A double-blind comparison of ntramuscular pethidine and nalbuphine in labour. Anaesthesia. 1986;41:1207–1213
  30. McGarry JM. A double-blind comparison of the anti-emetic effect during labour of metoclopramide and perphenazine. Br J Anaesth. 1971;43:613–615
  31. Vella L, Francis D, Houlton P, Reynolds F. Comparison of the antiemetics metoclopramide and promethazine in labour. Br Med J. 1985;290:1173–1175
  32. Rosenblatt WH, Cioffi AM, Sinatra R, Saberski LR, Silverman DG. Metoclopramide: an analgesic adjunct to patient-controlled analgesia. Anesth Analg. 1991;73:553–555
  33. Kariniemi V, Ammala P. Effects of intramuscular pethidine on fetal heart rate variability during labour. Br J Obstet Gynaecol. 1981;88:718–720
  34. Reynolds F, Sharma SK, Seed PT. Analgesia in labour and fetal acid-base balance: a meta-analysis comparing epidural with systemic opioid analgesia. Br J Obstet Gynaecol 971-4.2002; 109:1344–53.
  35. Brackbill U, Kane J, Manniello RL, Abramson D. Obstetric meperidine usage and assessment of neonatal status. Anesthesiology. 1974;40:116–120
  36. Wiener PC, Hogg MIJ, Rosen M. Effects of naloxone on pethidine-induced neonatal depression. Br Med J. 1977;2:228–231
  37. Nissen E, Lilja G, Mattiesen AS, Ransjo-Arvidsson AB, Uvnas-Moberg K, Widstrom AM. Effects of maternal pethidine on infants’ developing breast feeding behaviour. Acta Paediatr. 1995;84:140–145
  38. Nissen E, Widstrom AM, Lilja G, et al. Effects of routinely given pethidine during labour on infants’ developing breastfeeding behaviour. Effects of dose-delivery time interval and various concentrations of pethidine / norpethidine in cord plasma. Acta Paediatr. 1997;86:201–208
  39. Hafstrom M, Kjellmer I. Non-nutritive sucking by infants exposed to pethidine in utero. Acta Paediatr. 2000;89:1196–2000
  40. Baumgarder DJ, Muehl P, Fischer M, Pribbenow B. Effect of labor epidural anesthesia on breast-feeding of healthy full-term newborns delivered vaginally. J Am Board Fam Pract. 2003;16:7–13
  41. Beilin Y, Bodian CA, Weisner J, et al. Effect of labor epidural analgesia with and without fentanyl on infant breast-feeding: a prospective, randomized, double-blind study. Anesthesiology. 2005;103:1211–1217
  42. Volmanen P, Valanne J, Alahuhta S. Breast-feeding problems after epidural analgesia for labour: a retrospective cohort study of pain, obstetrical procedures and breast-feeding practices. Int J Obstet Anesth. 2004;13:25–29
  43. Henderson JJ, Dickinson JE, Evans SF, McDonald SJ, Paech MJ. Impact of intrapartum epidural analgesia on breast feeding duration. Aust NZ J Obstet Gynaecol. 2003;43:372–377
  44. Torvaldsen S, Roberts CL, Simpson JM, Thompson JF, Ellwood DA. Intrapartum epidural analgesia and breastfeeding: a prospective cohort study. Int Breastfeed J. 2006;1:24
  45. Chang ZM, Heaman MI. Epidural analgesia during labor and delivery: effects on the initiation and continuation of effective breastfeeding. J Hum Lact. 2005;21:305–314
  46. NICE Guideline on Intrapartum Care: management and delivery of care to women in labour. Draft for consultation June 2006 1.4.14, 1.5.4, 1.5.8.
  47. Goldhill DR, McNarry AF, Mandersloot G, McGinley A. A physiologically-based early warning score for ward patients: the association between score and outcome. Anaesthesia. 2005;60:547–553
  48. Quarterman CP, Thomas AN, McKenna M, McNamee R. Use of a patient information system to audit the introduction of modified early warning scoring. J Eval Clin Pract. 2005;11:133–138
  49. Ross A. Maternal satisfaction with labour analgesia. Baillières Clin Obstet Gynaecol. 1998;12:499–512

PII: S0959-289X(07)00124-0

doi: 10.1016/j.ijoa.2007.05.014

International Journal of Obstetric Anesthesia
Volume 17, Issue 1 , Pages 3-8 , January 2008

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