International Journal of Obstetric Anesthesia
Volume 18, Issue 2 , Pages 125-130 , April 2009

ED95 of phenylephrine to prevent spinal-induced hypotension and/or nausea at elective cesarean delivery

  • M. Tanaka

      Affiliations

    • Corresponding Author InformationCorrespondence to: Jose C. A. Carvalho, M.D., Department of Anesthesia and Pain Management, Mount Sinai Hospital, 600 University Avenue, Room 781, Toronto, Ontario, M5G 1X5, Canada. Tel.: +416 586 5270; fax: +416 586 8664.
    • ,
  • M. Balki
    • ,
  • R.K. Parkes
    • ,
  • J.C.A. Carvalho

,Accepted 28 September 2008.

References 

  1. Clark RB, Thompson DS, Thompson CH. Prevention of spinal hypotension associated with cesarean section. Anesthesiology. 1976;45:670–674
  2. Macarthur A, Riley ET. Obstetric anesthesia controversies: vasopressor choice for postspinal hypotension during cesarean delivery. Int Anesthesiol Clin. 2007;45:115–132
  3. James FM, Greiss FC, Kemp RA. An evaluation of vasopressor therapy for maternal hypotension during spinal anesthesia. Anesthesiology. 1970;33:25–34
  4. Ralson DH, Shnider SM, deLorimer AA. Effect of equipotent ephedrine, metaraminol, mephentermine, and methoximime on uterine blood flow in the pregnant ewe. Anesthesiology. 1974;40:354–370
  5. Cooper DW, Carpenter M, Mowbray P, Desira WR, Ryall DM, Kokri MS. Fetal and maternal effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Anesthesiology. 2002;97:1582–1590
  6. Ngan Kee WD, Khaw KS. Vasopressors in obstetrics: what should we be using?. Curr Opin Anaesthesiol. 2006;19:238–243
  7. Taylor JC, Tunstall ME. Dose of phenylephine in spinal anaesthesia for caesarean section. Anaesthesia. 1991;46:314–316
  8. Morgan P. The role of vasopressors in the management of hypotension induced by spinal and epidural anaesthesia. Can J Anaesth. 1994;41:404–413
  9. Hall PA, Bennett A, Wilkes MP, Lewis M. Spinal anaesthesia for caesarean section: comparison of infusions of phenylephrine and ephedrine. Br J Anaesth. 1994;73:471–474
  10. Moran DH, Perillo M, LaPorta RF, Bader AM, Datta S. Phenylephrine in the prevention of hypotension following spinal anesthesia for cesarean delivery. J Clin Anesth. 1991;3:301–305
  11. Thomas DG, Robson SC, Redfern N, Hughes D, Boys HR. Randomized trial of bolus phenylephrine or ephedrine for maintenance of arterial pressure during spinal anaesthesia for caesarean section. Br J Anaesth. 1996;76:61–65
  12. Ramanathan S, Grant GJ. Vasopressor therapy for hypotension due to epidural anesthesia for cesarean section. Acta Anaesthesiol Scand. 1988;32:559–565
  13. Ivanova A, Montazer-Haghighi A, Durham SD. Improved up and down designs for phase I trials. Stat Med. 2003;22:69–82
  14. Firth D. Bias reduction of maximum likelihood estimates. Biometrika. 1993;80:27–38
  15. Heinze G, Schemper M. A solution to the problem of separation in logistic regression. Stat Med. 2002;21:2409–2419
  16. The R Foundation for Statistical Computing. Available from URL; http://cran.r-project.org.
  17. Bull SB, Lewinger JP, Lee SSF. Confidence intervals for multinomial logistic regression in sparse data. Stat Med. 2007;26:903–918
  18. Heinze G. A comparative investigation of methods for logistic regression with separated or nearly separated data. Stat Med. 2006;25:4216–4226
  19. Lee A, Ngan Kee WD, Gin T. A quantitative, systemic review of randomized controlled trials of ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean delivery. Anesth Analg. 2002;94:920–926
  20. Balki M, Kasodekar S, Dhumne S, Carvalho JCA. Prophylactic granisetron does not prevent postdelivery nausea and vomiting during elective cesarean delivery under spinal anesthesia. Anesth Analg. 2007;104:679–683
  21. Balki M, Carvalho JCA. Intraoperative nausea and vomiting during cesarean section under regional anesthesia. Int J Obstet Anesth. 2005;14:230–241
  22. Ngan Kee WD, Khaw KS, Ng FF. Comparison of phenylephrine infusion regimens for maintaining maternal blood pressure during spinal anaesthesia for caesarean section. Br J Anaesth. 2004;92:469–474
  23. Ngan Kee WD, Khaw KS, Ng FF. Prevention of hypotension during spinal anesthesia for cesarean delivery. Anesthesiology. 2005;103:744–750
  24. Columb MO, D’Angelo R. Up-down studies: responding to dosing! [debate]. Int J Obstet Anesth. 2006;15:129–136
  25. Columb MO, Thomson HE. Confidence with confidence intervals. Br J Anaesth. 2005;95:111–112

☆ Presented in part as poster presentation at the Society for Obstetric Anesthesia and Perinatology 39th Annual meeting, Banff, Alberta, May 16–19, 2007.

PII: S0959-289X(08)00157-X

doi: 10.1016/j.ijoa.2008.09.008

International Journal of Obstetric Anesthesia
Volume 18, Issue 2 , Pages 125-130 , April 2009

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