International Journal of Obstetric Anesthesia
Volume 19, Issue 1 , Pages 56-60 , January 2010

Reduction of severity of pruritus after elective caesarean section under spinal anaesthesia with subarachnoid morphine: a randomised comparison of prophylactic granisetron and ondansetron

  • T. Tan

      Affiliations

    • Corresponding Author InformationCorrespondence to: Terry Tan, Department of Anaesthesia and Perioperative Medicine, Coombe Women and Infants University Hospital, Dublin, Ireland. Tel.: +353 1 4085200; fax: +353 1 4536033.
    • ,
  • R. Ojo
    • ,
  • S. Immani
    • ,
  • P. Choroszczak
    • ,
  • M. Carey

,Accepted 18 May 2009.

References 

  1. Sarvela PJ, Halonen PM, Soikkeli A, Korttila K. A double blind, randomized comparison of intrathecal and epidural morphine for elective Caesarean delivery. Anesth Analg. 2002;95:436–440
  2. Scott PV, Fischer HB. Spinal opiate analgesia and facial pruritus: a neural theory. Postgrad Med J. 1982;58:531–535
  3. Kyriakides K, Hussain SK. Hobbs GJ: Management of opioid-induced pruritus: a role for 5-HT3 antagonists?. Br J Anaesth. 1999;82:439–441
  4. Yeh HM, Chen LK, Lin CJ, et al. Prophylactic intravenous ondansetron reduces the incidence of intrathecal morphine-induced pruritus in patients undergoing cesarean delivery. Anesth Analg. 2000;91:172–175
  5. Charuluxananan S, Kyokong O, Somboonviboon W, Narasethakamol A, Promlok P. Nalbuphine versus ondansetron for prevention of intrathecal morphine-induced pruritus after cesarean delivery. Anesth Analg. 2003;96:1789–1793
  6. Yazigi A, Chalhoub V, Madi-Jebara S, Haddad F, Hayek G. Prophylactic ondansetron is effective in the treatment of nausea and vomiting but not on pruritus after cesarean delivery with intrathecal sufentanil-morphine. J Clin Anesth. 2002;14:183–186
  7. Sarvela PJ, Halonen PM, Soikkeli AI, Kainu JP, Korttila KT. Ondansetron and tropisetron do not prevent intraspinal morphine- and fentanyl-induced pruritus in elective cesarean delivery. Acta Anaesthesiol Scand. 2006;50:239–244
  8. Slappendel R, Weber EW, Benraad B, van Limbeek J, Dirksen R. Itching after intrathecal morphine. Incidence and treatment. Eur J Anaesthesiol. 2000;17:616–621
  9. Siddik-Sayyid SM, Aouad MT, Taha SK, et al. Does ondansetron or granisetron prevent subarachnoid morphine-induced pruritus after cesarean delivery?. Anesth Analg. 2007;104:421–424
  10. Iatrou CA, Dragoumanis CK, Vogiatzaki TD, Vretzakis GI, Simpoulos CE, Dimitriou VK. Prophylactic intravenous ondansetron and dolasetron in intrathecal morphine-induced pruritus: a randomized, double blinded placebo-controlled study. Anesth Analg. 2005;101:1516–1520
  11. Szarvas S, Harmon D, Murphy D. Neuraxial opioid-induced pruritus: A review. J Clinical Anesth. 2003;15:234–239
  12. Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia: Lippincott Williams and Wilkins; 2005: 742, 1210.
  13. Bonnet MP, Marret E, Josserand J, Mercier FJ. Effect of prophylactic 5-HT3 receptor antagonist on pruritus induced by neuraxial opioids: a quantitative systematic review. Br J Anaesth. 2008;101:311–319
  14. Colbert S, O’Hanlon DM, Chambers F, Moriarty DC. The effect of rectal diclofenac on pruritus in patients receiving intrathecal morphine. Anaesthesia. 1999;54:948–952

 This work was presented at the Irish Congress of Anaesthesia on 15th May 2008.

PII: S0959-289X(09)00119-8

doi: 10.1016/j.ijoa.2009.05.005

International Journal of Obstetric Anesthesia
Volume 19, Issue 1 , Pages 56-60 , January 2010

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