International Journal of Obstetric Anesthesia
Volume 19, Issue 3 , Pages 254-260 , July 2010

The influence of ATP-binding cassette sub-family B member -1 (ABCB1) genetic polymorphisms on acute and chronic pain after intrathecal morphine for caesarean section: a prospective cohort study

  • A.T. Sia

      Affiliations

    • KK Research Centre, Department of Women’s Anaesthesia, KK Women’s and Children’s Hospital, Singapore
    • Corresponding Author InformationCorrespondence to: Dr. Alex T. Sia, Department of Women’s Anaesthesia, KK Women’s and Children’s Hospital, 100 Bukit Timah Road, Singapore 229 899, Singapore.
    • ,
  • B.L. Sng

      Affiliations

    • KK Research Centre, Department of Women’s Anaesthesia, KK Women’s and Children’s Hospital, Singapore
    • ,
  • E.C. Lim

      Affiliations

    • KK Research Centre, Department of Women’s Anaesthesia, KK Women’s and Children’s Hospital, Singapore
    • ,
  • H. Law

      Affiliations

    • Genetic Services, KK Women’s and Children’s Hospital, Singapore
    • ,
  • E.C. Tan

      Affiliations

    • KK Research Centre, Department of Women’s Anaesthesia, KK Women’s and Children’s Hospital, Singapore

,Accepted 3 March 2010.

References 

  1. Klepstad P, Dale O, Skorpen F, Borchgrevnik PC, Kaasa S. Genetic variability and clinical efficacy of morphine. Acta Anaesthesiol Scand. 2005;49:902–908
  2. Thompson SJ, Koszdin K, Bernards CM. Opiate induced analgesia is increased and prolonged in mice lacking p-glycoprotein. Anesthesiology. 2000;92:1392–1399
  3. Liang D, Liao G, Lighthall GK, Peltz G, Clark DJ. Genetic variants of the P-glycoprotein gene Abcb1 modulate opioid induced hyepralgesia, tolerance and dependence. Pharmacogenet Genomics. 2006;16:825–835
  4. Sng BL, Sia ATH, Woo D, Lim Y. Incidence and risk factors for chronic pain after caesarean section under spinal anaesthesia. Anaesth Intensive Care. 2009;37:748–752
  5. Tan EC, Lim EC, Teo YY, Lim Y, Law HY, Sia AT. Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain. Mol Pain. 2009;5:32
  6. Nikolajsen L, Sorensen HC, Jensen TS, Kehlet H. Chronic pain following Caesarean section. Acta Anaesthesiol Scand. 2004;48:111–116
  7. Seo T, Ishitsu T, Ueda N, et al. ACBC1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients. Pharmacogenomics. 2006;7:551–561
  8. Somogyi A, Baratt DT, Coller JK. Pharmacogenetics of opioids. Clin Pharmacol Ther. 2007;81:429–444
  9. Fung KL, Gottesman MM. A synonymous polymorphism in a common MRD1 (ABCB1) haplotype shapes protein function. Biochim Biophys Acta. 2009;1794:860–871
  10. Kimchi-Sarfaty C, Marple AH, Shinar S, et al. Ethnicity-related polymorphisms and haplotypes in the human ABCB1 gene. Pharmacogenomics. 2007;8:29–39
  11. Tanabe M, Ieiri I, Nagata N, et al. Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene. J Pharmacol Exp Ther. 2001;297:1137–1143
  12. Kosarac B, Fox AA, Collard CD. Effect of genetic factors on opioid action. Curr Opin Anaesthesiol. 2009;22:476–482
  13. Coulbault L, Beaussier M, Verstuyft C, et al. Environmental and genetic factors associated with morphine response in the postoperative period. Clin Pharmacol Ther. 2006;79:316–324
  14. Campa D, Gioia A, Tomei A, Poli P, Barale R. Associations of ABCB1/MDR and OPRM1 gene polymorphisms with morphine pain relief. Clin Pharmacol Ther. 2008;83:559–566
  15. Lotsch J, von Hentig N, Freynhagen R, et al. Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers. Pharmacogenet Genomics. 2009;19:429–436
  16. Chu LF, Clark DJ, Angel MS. Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: a preliminary prospective study. J Pain. 2008;7:43–48
  17. Angst MS, Kopperl W, Pahl I, Clark DJ, Schmetz M. Short term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. Pain. 2003;106:49–57

PII: S0959-289X(10)00027-0

doi: 10.1016/j.ijoa.2010.03.001

International Journal of Obstetric Anesthesia
Volume 19, Issue 3 , Pages 254-260 , July 2010

Article Tools