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Summary
The administration of intravenous dantrolene in a parturient susceptible to malignant hyperthermia has been associated with post partum uterine atony. We examined the effect of dantrolene sodium for injection (Dantrium Intravenous) on spontaneous contractility of uterine smooth muscle from women in term pregnancy in an isolated preparation. Dantrolene sodium for injection at 5 μg/ml and 10 μg/ml had no effect on the spontaneous contractility of the uterine muscle preparations. At a cumulative concentration of 20 μg/ml, a mild depression (16 ± 14%) in the frequency of spontaneous contractions was noted. However, a similar depression in the muscle preparations treated with mannitol suggests that the depression observed with the dantrolene was likely due to the mannitol that was included in the dantrolene formulation rather than to dantrolene sodium itself. We conclude that dantrolene sodium has no effect on the spontaneous contractility of uterine smooth muscle. The depression of uterine muscle activity observed with dantrolene for injection appears attributable to the mannitol.
References
- Malignant hyperthermia: A review of published cases.Anesth Analg. 1993; 77: 297-304
- Dantrolene in human malignant hyperthermia.Anesthesiology. 1982; 56: 254-262
- Dantrolene dose response in awake man: Implications for management of malignant hyperthermia.Anesthesiology. 1983; 59: 275-280
- Controversies in malignant hyperthermia.Anesthesiology. 1983; 59: 273-274
- Post-partum uterine atony after intravenous dantrolene.Anesth Analg. 1987; 66: 269-270
- More on malignant hyperthermia during delivery.Am J Obstet Gynecol. 1985; 152: 608-609
- Dantrolene sodium: Stimulatory and depressant effects on the contractility of guinea-pig uterus in vitro.Eur J Pharmacol. 1983; 92: 291-294
- The effects of dantrolene sodium on cardiac and skeletal muscle in rats.Eur J Pharmacol. 1976; 39: 127-131
- Dantrolene blocks intracellular calcium release in smooth muscle: Competitive antagonism of thromboxane A2.Can J Physiol Pharmacol. 1978; 56: 520-523
- Effect of dantrolene sodium on the contractility of rabbit jejunum in vitro.Eur J Pharmacol. 1981; 70: 287-292
- Malignant hyperthermia in pregnancy.Am J Obstet Gynecol. 1984; 150: 327-328
- Increased carbon dioxide production in two patients with malignant hyperthermia and its control by dantrolene.Br J Anaesth. 1979; 51: 899-903
- Malignant hyperthermia triggered by cyclopropane during cesarean section.Anesthesiology. 1982; 56: 144-146
- Malignant hyperthermia.Science. 1992; 256: 789-794
- Effects of dantrolene on myoplasmic free [Ca2+] measured in vivo in patients susceptible to malignant hyperthermia.Anesthesiology. 1992; 76: 711-719
- Intravenous dantrolene pharmacokinetics in malignant hyperthermia suspect patients.Anesthesiology. 1985; 63: A300
- Dantrolene.Can Anaesth Soc J. 1984; 31: 61-75
- Intravenous dantrolene in a pregnant malignant hyperthermia susceptible (MHS) patient.Anesthesiology. 1984; 61: A404
- The anaesthetic management of the malignant hyperthermia susceptible parturient.Can Anaesth Soc J. 1986; 33: 371-378
- Pregnancy and malignant hyperthermia.J Clin Anesth. 1992; 4: 173
- The cardiovascular effects of dantrolene sodium in dogs.Anaesthesia. 1975; 30: 318-322
- Effect of dantrolene sodium on canine bladder contractility.Urology. 1980; 16: 229-231
- Skeletal muscle relaxants.in: Gennaro AR Remington's pharmaceutical sciences. Mack Publishing Co, London1985: 922-923
- Dantrolene — Dynamics and Kinetics.Br J Anaesth. 1988; 60: 279-286
- Lecithin-coated dantrolene sodium microcrystals vs. dantrolene sodium: Dose-response to muscular twitch in swine.Anesthesiology. 1993; 79: A438
- Effect of urea, glycerol, and mannitol on basilar and labyrinthine arteries.Otolaryngol Head Neck Surg. 1988; 98: 226-230
- Effects of mannitol on intracerebral arteriolar diameter in vitro: Extraluminal and intraluminal application.Neurosurgery. 1989; 25: 747-752
- Mechanism underlying mannitol-induced relaxation in isolated monkey cerebral arteries.Am J Physiol. 1992; 262: H897-H902
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