Henoch–Schonlein purpura (HSP) is a small vessel vasculitis characterised by the deposition
of IgA antibodies and immune complexes in blood vessels and renal mesangium.
1
It affects children more commonly than adults, although it can occur at any age.
2
The classic triad of HSP is that of purpura, arthritis and abdominal pain. HSP nephritis
is a common complication which may lead to renal failure.
3
There is also an associated risk of haemorrhagic complications involving lungs, brain,
gastrointestinal tract and urinary system.
4
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References
- Clinical update: Henoch–Schönlein purpura.Lancet. 2007; 369: 976-978
- Henoch–Schönlein purpura in adults.Am J Kidney Dis. 2006; 48: 1009-1016
- Long-term follow-up of childhood Henoch–Schonlein nephritis.Lancet. 1992; 339: 280-282
- Cerebral hemorrhage in Henoch–Schönlein syndrome.Childs Nerv Syst. 2002; 18: 365-367
- Laboratory signs of activated coagulation are common in Henoch–Schonlein purpura.Pediatr Nephrol. 2001; 16: 1084-1088
- Henoch–Schonlein purpura in pregnancy.J Obstet Gynaecol. 2008; 28: 403-405
Article info
Publication history
Published online: September 12, 2011
Accepted:
July 12,
2011
Identification
Copyright
© 2011 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
