Highlights
- •Seventy-three pregnant women received sugammadex in non-obstetric surgery.
- •Sugammadex was not associated with miscarriage or preterm labor within four weeks.
- •Missing data may have obscured potential adverse outcomes from sugammadex exposure.
- •The findings do not exclude sugammadex-related adverse pregnancy outcomes.
Abstract
Background
The influence of sugammadex exposure during pregnancy on progesterone withdrawal and
miscarriage is unknown. We aimed to compare the fetal outcomes in pregnant patients
who had undergone non-obstetric surgery with and without sugammadex.
Methods
We retrospectively reviewed the medical charts of pregnant women who underwent non-obstetric
surgery at three tertiary perinatal care centers in Japan from January 2013 to December
2020. The women were divided into those who received general anesthesia with sugammadex
(GA with SGX) and those who received general anesthesia without sugammadex (GA without
SGX). We compared miscarriages and preterm births within four weeks after surgery.
Results
Among the 124 women, 73 and 51 were included in the GA with SGX and GA without SGX
groups, respectively. The two groups showed no differences in the rate of miscarriages
or preterm births (3.0 % vs 4.3 %; odds ratio 1.42, 95 % confidence interval 0.19
to 10.47; P = 1.00). The SGX and no SGX groups were missing outcomes for 8.2 % and 7.8 % of cases,
respectively.
Conclusions
Having GA with SGX or GA without SGX did not result in different rates of miscarriage
or preterm birth within four weeks after the procedure. These findings do not exclude
a potential association between sugammadex exposure during pregnancy and adverse pregnancy
outcomes. Missing data may have obscured possible adverse outcomes from sugammadex
exposure.
Keywords
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Article info
Publication history
Published online: December 22, 2022
Accepted:
December 16,
2022
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
