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Original article| Volume 5, ISSUE 1, P14-18, January 1996

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Ketorolac and spinal morphine for postcesarean analgesia

  • S.E Cohen
    Correspondence
    Correspondence to: Dr Sheila E. Cohen.
    Footnotes
    Affiliations
    Departments of Anesthesia and Health Research and Policy, Stanford University, California, USA
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  • J.B Desai
    Footnotes
    Affiliations
    Departments of Anesthesia and Health Research and Policy, Stanford University, California, USA
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  • E.F Ratner
    Footnotes
    Affiliations
    Departments of Anesthesia and Health Research and Policy, Stanford University, California, USA
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  • E.T Riley
    Footnotes
    Affiliations
    Departments of Anesthesia and Health Research and Policy, Stanford University, California, USA
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  • J Halpern
    Footnotes
    Affiliations
    Departments of Anesthesia and Health Research and Policy, Stanford University, California, USA
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  • Author Footnotes
    1 S. E. Cohen, MB Ch B, FRCA, Professor of Anesthesia
    2 J B. Desai, MD, Fellow in Obstetric Anesthesia
    3 E. F. Ratner, MD, Assistant Professor of Anesthesia
    4 E. T Riley, MD, Clinical Assistant Professor of Anesthesia, Department of Anesthesia
    5 J Halpern, PhD, Senior Research Associate, Department of Health Research and Policy (Division of Biostatistics), Stanford University School of Medicine, Stanford, California, USA.
Open AccessDOI:https://doi.org/10.1016/S0959-289X(96)80069-0
Ketorolac and spinal morphine for postcesarean analgesia
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      Abstract

      This study was designed to compare spinal morphine (SM), ketorolac (K), and a combination of the two drugs with respect to analgesic efficacy and side effects in postcesarean patients. Forty-eight parturients having bupivacaine spinal anesthesia for cesarean delivery randomly received in a double-blind manner either: SM: 0.1 mg or SM: 0.2 mg (but no K); SM: 0.1 mg plus K 60 mg intravenously (i.v.) one hour after spinal injection, and 30 mg i.v. every 6 h for three doses or i.v. K dosed as previously described (but no SM). Analgesia and side effects were evaluated during the first 20 h. Forty-eight women were studied. There were no significant differences in analgesia among the groups, although patients receiving SM: 0.1 mg tended to have less satisfactory intraoperative analgesia. Pruritus was common in all patients receiving SM whereas patients who received K had the lowest overall scores for severity of side effects. No serious complications occurred and all groups expressed similarly high satisfaction at the 24 h visit. We conclude that there is no advantage to combining SM and K, and that K provides satisfactory postcesarean analgesia with few side effects.

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      DOI: https://doi.org/10.1016/S0959-289X(96)80069-0

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      © 1996 Published by Elsevier Inc.

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